Curcumin Enhances Memory Dysfunction Induced by Scopolamine in Female Rats

Spirulina Plathensis microalgae prevents scopolamine-induced memory impairment in young female Wistar rats

Introduction: Memory deficit is one of the clinical problems of Alzheimer’s disease that progressively leads to cognitive impairment and dementia. In the present study, the effect of Spirulina plathensis microalgae on the scopolamine-induced memory impairment was evaluated. Materials and Methods: Young female Wistar rats (30 days old) were used. Animals randomly were divided into 9 groups (Sali...

The effect of intracerebroventricular administration of insulin on memory impairment-induced by scopolamine in male rats

Introduction: Cholinergic neuronal deficiency is one of the main causes of Alzheimer's pathology, which leads to learning and memory impairment. Scopolamine is a muscarinic cholinergic antagonist commonly used to induce Alzheimer's disease (AD). Insulin also regulates learning and memory function. Thus, the aim of this study was to determine the effect of central administration of insulin on pa...

the protective effect of curcumin on scopolamine induced spatial learning and memory deficits in rats

background: the cholinergic system plays an important role in learning and memory. administration of extracts of curcuma longa or its constituent, curcumin, have some roles in cognitive function in animals. the aim of the present study was to investigate the effects of curcumin in preventing spatial performance impairment induced by scopolamine, a cholinergic receptor antagonist, in rats using ...

Curcumin-Loaded BSA Nanoparticles Protect More Efficiently Than Natural Curcumin Against Scopolamine-Induced Memory Retrieval Deficit

Introduction: There is evidence indicating that the rate of AD is lower in curry consuming populations. Then, there is an effort to elucidate if curcumin -as the main ingredient of turmeric- might affect the process of AD. However, in clinical trials of AD, a six-month curcumin treatment failed to show any progress, which might be attributable to its low bioavailability. In this line, a recent ...

Scopolamine-Induced Dry Eye Model in Female Rats